Shilpa Gupta, M.D. Internal Medicine Farmington, Everybody got operated within the eight to 10-week period and other immunotherapy trials have also alleviated this concern. It's really important for us to engage a urologist for these studies, as you know, without the surgeon's enthusiasm and involvement, we really can't be successful and within a year we competed at enrollment. We have the cohort of our trial, the BLASST-1, which is immunotherapy and chemotherapy and Dr. Peter Black, who's a collaborator from Vancouver, he has a cohort of his patients who received only gem-cis chemotherapy and Dr. Andrea Necchi from Italy has done single-agent pembrolizumab trial in the same setting. Yes, absolutely. What have you found, and how have you managed to offset their concerns? Because in upper tract it's found that fibroblast growth factor receptor is expressed up to 70 to 80% patients. Im Profil von Shilpa Gupta sind 3 Jobs angegeben. Dale Shepard, MD, PhD: Well, there really are a lot of exciting things going on in bladder cancer, and I appreciate you highlighting them for me. More recently at the annual ASCO meeting, we saw that in the maintenance setting in metastatic urothelial cancer, patients who get first-line platinum-based chemotherapy, which is the current standard, anybody who progresses after that, we already have single agent immunotherapy approved. Shilpa Gupta, MD: But we do. We enrolled 41 patients between February, 2018 and June, 2019 with muscle-invasive bladder cancer. Please join us again soon. Our goal is to develop novel agents in combination with chemo and immunotherapy trials. Are they leery to enroll in trials that delay surgery? More importantly, the combination was very safe with no increased toxicities from the combination. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. Dr. Gupta obtained her Medical Degree at the Lady Hardinge Medical College in New Delhi, India and completed a residency in Internal Medicine at the University of Connecticut Health Center. Please join us again soon. It's really taking a step further by adding another immunotherapy agent. Dale Shepard, MD, PhD: It does seem to be a common question, doesn't it? 2001, Genitourinary Cancers: Bladder Cancer, prostate Cancer, Kidney Cancer, Testicular Cancer, (Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. Our patients here know that in any case, even if they don't go on a trial, 12 weeks of chemotherapy is standard, and after that, within six to eight weeks, they get operated upon. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page. More recently at the annual ASCO meeting, we saw that in the maintenance setting in metastatic urothelial cancer, patients who get first-line platinum-based chemotherapy, which is the current standard, anybody who progresses after that, we already have single agent immunotherapy approved. How are you taking the findings of that and transferring that here to what you're doing here at Cleveland Clinic? Yeah, absolutely. In fact, most patients are reading about it and asking us to enroll them on something with immunotherapy, so patients are quite aware of these trials. What was the key to the success in getting this trial to happen? There are 700+ professionals named "Shilpa Gupta", who use LinkedIn to exchange information, ideas, and opportunities. This was an investigator-initiated trial that I led. Shilpa has 2 jobs listed on their profile. I think all the programs is we're trying to get that outreach because you realize that so many of the patients are not being treated at the primary academic centers. Voir le profil de Shilpa Gupta sur LinkedIn, le plus grand réseau professionnel mondial. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Thanks for the opportunity. Shilpa Gupta, MD: Thanks, Dale. All the urology colleagues, radiation oncology colleagues, Dr. Mian, who actually is leading another Department of Defense TTSA grant this year, and I'm the co-PI on that along with Dr. Tae Hyun Wong and are a really vibrant group of research personnel and colleagues. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. 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